Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Trimethylsilyldiazomethane → Methyl 2-acetamidoisonicotinate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Trimethylsilyldiazomethane | HCID 167693 | — |
| 반응물 | 2-Acetamidopyridine-4-carboxylic acid | HCID 3774466 | — |
| 용매 | Benzene methanol | HCID 21927730 | — |
| 생성물 | Methyl 2-acetamidoisonicotinate | HCID 22185175 | — |
반응 단계
4-Carboxy-2-acetylaminopyridine (3.4 g, 19 mmol) was dissolved in methanol/benzene (100 mL, 1:1). TMS-diazomethane was added (1M, Aldrich) with cooling until the yellow color just persisted, then the solvent was removed under reduced pressure. The product was purified by silica gel column chromatography (50/50 hexane/ethyl acetate) and 3.0 g of product was recovered.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05972975 |
| 출처 데이터셋 | uspto-grants-1999_10 |
| ORD ID | ord-5841a4b889fc4ec4832020a9bd18915c |
| 출처 메모 | uspto-grants-1999_10 |