Sodium Cyanide → 6-Amino-4-methylnicotinonitrile
반응식
[NH2:1][C:2]1[CH:7]=[C:6]([CH3:8])[C:5](Br)=[CH:4][N:3]=1.[Cu][C:11]#[N:12].[C-]#N.[Na+]>CN(C)C=O.O>[NH2:1][C:2]1[CH:7]=[C:6]([CH3:8])[C:5]([C:11]#[N:12])=[CH:4][N:3]=1참가 물질
6
실험 절차
A mixture of 2-amino-5-bromo-4-methylpyridine (4.0 g, 21.4 mmol) and copper(I) cyanide (2.2 g, 24.6 mmol) in N,N-dimethylformamide (5 mL) was stirred for 4 h at reflux temperature. The hot mixture was poured into a warm solution of sodium cyanide (4.3 g) in water (13 mL). After the mixture was vigorously shaken, the mixture was extracted with ethyl acetate. The organic extract was washed with 10% aqueous sodium cyanide, saturated brine solution and evaporated. The title compound was obtained as a solid after chromatography on silica gel (15% acetone/hexane); yield 1.81 g (64%).
후처리
- temperatureat reflux temperature
- stirringAfter the mixture was vigorously shaken
- extractionthe mixture was extracted with ethyl acetate
- extractionThe organic extract
- washwas washed with 10% aqueous sodium cyanide, saturated brine solution
- customevaporated
출처 및 근거
- ORD 기록
- ord-91262695ff1a4c09be98dce544f04b85
- 출처 데이터셋
- uspto-grants-1999_10
- 특허 번호
- US05972975
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