Pyridine → N-(4-Bromo-l-methyl-5-pyrazolyl)-S,S-dimethylsulfilimine

HRID 1741263

반응식

HRID 1741263 반응식
[CH3:1][S:2][CH3:3].ClCl.[NH2:6][C:7]1[N:11]([CH3:12])[N:10]=[CH:9][C:8]=1[Br:13].N1C=CC=CC=1>ClCCl>[Br:13][C:8]1[CH:9]=[N:10][N:11]([CH3:12])[C:7]=1[N:6]=[S:2]([CH3:3])[CH3:1]

참가 물질

6

반응물 4

HCID 1049PyridineHCID 1068Dimethyl SulfideHCID 24526ChlorineHCID 6003514-Bromo-1-methyl-1H-pyrazol-5-amine

생성물 1

HCID 23303942N-(4-Bromo-l-methyl-5-pyrazolyl)-S,S-dimethylsulfilimine

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of 0.60 mL (8.2 mmol) of dimethyl sulfide in 30 mL of dichloromethane was cooled to -20° C. and 0.50 g (7.0 mmol) of chlorine was added through a sparge tube with cooling and stirring. Subsequently, 1.0 g (5.7 mmol) of 5-amino-4-bromo-l-methylpyrazole and then 1.0 g (12.7 mmol) of pyridine were added with cooling and stirring. A 2 mL aliquot of this mixture was removed and the light yellow solids present were collected by filtration and washed with deuteroacetonitrile.

후처리

  1. temperaturewith cooling
  2. temperaturewith cooling
  3. stirringstirring
  4. customA 2 mL aliquot of this mixture was removed
  5. filtrationthe light yellow solids present were collected by filtration
  6. washwashed with deuteroacetonitrile

출처 및 근거

ORD 기록
ord-a70216e9faf0426ea55ddb0fffc328a2
출처 데이터셋
uspto-grants-1999_10
특허 번호
US05973148

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