Ethanol → HCID 21835786, 화합물

HRID 1741345노트

반응식

HRID 1741345 반응식
[C:1]([CH:4]=[N:5][C:6]1[C:7](=[CH:11][CH:12]=[C:13]([Cl:15])[CH:14]=1)[C:8]([OH:10])=[O:9])([OH:3])=[O:2].S(=O)(=O)(O)O.[CH2:21](O)[CH3:22]>>[C:1]([CH:4]=[N:5][C:6]1[C:7](=[CH:11][CH:12]=[C:13]([Cl:15])[CH:14]=1)[C:8]([OH:10])=[O:9])([O:3][CH2:21][CH3:22])=[O:2]

참가 물질

4

반응물 3

HCID 702EthanolHCID 1118Sulfuric Acid2회HCID 19597249HCID 19597249, 화합물

생성물 1

HCID 21835786HCID 21835786, 화합물수율 73%

실험 절차

74.5 g (324.8 mmol) of N-carboxymethylene-4-chloroanthranilic acid are suspended in 1660 g of ethanol, 2.9 g (2.96 mmol) of concentrated sulfuric acid are added and the mixture is heated at the boiling point for 10 hours. After a reaction time of 5 hours, the same amount of sulfuric acid is again added. After 10 hours, the ethanol is distilled off and the product which precipitates out is filtered off in the cold and washed with cold ethanol. 55.5 g (0.22 mol, 73%) of N-carboethoxymethylene-4-chloro-anthranilic acid are obtained.

후처리

  1. temperaturethe mixture is heated at the boiling point for 10 hours
  2. distillationthe ethanol is distilled off
  3. customthe product which precipitates out
  4. filtrationis filtered off in the cold
  5. washwashed with cold ethanol

출처 및 근거

ORD 기록
ord-bcafaaa5244e43208bf4d3b96253f486
출처 데이터셋
uspto-grants-1999_10
특허 번호
US05973189

반응 노트

불러오는 중…