Boron tribromide → Ethyl 3-(bromomethyl)phenoxyacetate
반응식
O[CH2:2][C:3]1[CH:4]=[C:5]([O:9][CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])[CH:6]=[CH:7][CH:8]=1.B(Br)(Br)[Br:17]>ClCCl>[Br:17][CH2:2][C:3]1[CH:4]=[C:5]([O:9][CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])[CH:6]=[CH:7][CH:8]=1참가 물질
4
실험 절차
To a solution of 3-hydroxymethyl-1-ethoxycarbonylmethoxybenzene (1 g) in dichloromethane (10 ml) was added BBr3 (0.45 ml). After 1 hour, the solvent was evaporated in vacuo and the residue was dissolved in ethyl acetate. The organic layer was washed with NaHCO3 and brine. The dried solvent was evaporated in vacuo to give 3-bromomethyl-1-ethoxycarbonylmethoxybenzene (0.76 g). NMR (CDCl3, δ): 1.29 (3H, t, J=7 Hz), 4.24 (2H, d, J=7 Hz), 4.61 (2H, s), 5.00 (1H, d, J=3.0 Hz), 5.05 (1H, d, J=3.0 Hz), 6.7-7.1 (3H, m), 7.2-7.3 (1H, m)
후처리
- customthe solvent was evaporated in vacuo
- dissolutionthe residue was dissolved in ethyl acetate
- washThe organic layer was washed with NaHCO3 and brine
- customThe dried solvent was evaporated in vacuo
출처 및 근거
- ORD 기록
- ord-93b1b64c9a5a44ce8317c9d9c79cee76
- 출처 데이터셋
- uspto-grants-1999_10
- 특허 번호
- US05972965
반응 노트
불러오는 중…