Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1,2-Dichloroethane → 3-t-Butoxycarbonylamino-2-(RS)-[(Naphth-2-ylmethyl)-1H-imidazol-5-yl]acetylamino-propionic acid methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1,2-Dichloroethane | HCID 11 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 3-hydroxy-1,2,3-benzotriazin-4(3H)-one | HCID 73026 | — |
| 반응물 | Methyl 2-amino-3-[(2-methylpropan-2-yl)oxycarbonylamino]propanoate | HCID 3442239 | — |
| 반응물 | 1-(2-naphthylmethyl)-1H-imidazol-5-ylacetic acid hydrochloride | HCID 70206205 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 3-t-Butoxycarbonylamino-2-(RS)-[(Naphth-2-ylmethyl)-1H-imidazol-5-yl]acetylamino-propionic acid methyl ester | HCID 67571717 | — |
반응 단계
To a solution of 2-[l-(Naphth-2-ylmethyl)-1H-imidazol-5-yl]acetic acid hydrochloride (3.83 g, 12.7 mmol), 3-t-butoxycarbonylamino-2(R,S)- aminopropionic acid methyl ester (3.33 g, 15.3 mmol), HOOBT (2.30 g, 14.1 mmol), and triethylamine (5.80 ml, 42.0 mmol) in DMF (150 ml) at 0° C., was added EDC (2.67 g, 13.9 mmol). The reaction was stirred at room temperature for 18 hrs, diluted with EtOAc and the organic layer washed with sat. aq NaHCO3, brine, dried (Na2SO4), and the solvent evaporated in vacuo. The residue was chromatographed (SiO2, 5% MeOH in CH2Cl2) to afford the title compound as a white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05972984 |
| 출처 데이터셋 | uspto-grants-1999_10 |
| ORD ID | ord-1719258bfaf7426085c3f2ab912e3158 |
| 출처 메모 | uspto-grants-1999_10 |