HCID 19010813, 화합물 → HCID 19010736, 화합물

HRID 1741838노트

반응식

HRID 1741838 반응식
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([CH:9]=[C:10]([CH3:12])[CH3:11])[CH:6]=[CH:5][C:4]=1[C:13](=[O:18])[CH2:14][CH2:15][CH2:16][CH3:17]>[Pd]>[CH2:9]([C:7]1[CH:6]=[CH:5][C:4]([CH:13]([OH:18])[CH2:14][CH2:15][CH2:16][CH3:17])=[C:3]([O:2][CH3:1])[CH:8]=1)[CH:10]([CH3:12])[CH3:11]

참가 물질

3

반응물 1

HCID 19010813HCID 19010813, 화합물

생성물 1

HCID 19010736HCID 19010736, 화합물수율 98.4%

시약·촉매·용매 1

HCID 23938Palladium촉매

실험 절차

A mixture of 2'-methoxy-4'-(2-methyl-1-propenyl)valerophenone (88 mg) and 10% palladium on carbon (30 mg) was stirred under hydrogen atmosphere for 30 minutes. Catalyst was removed by filtration and the filtrate was concentrated. The residue was dissolved in methanol (5 ml) and then sodium borohydride (16 mg) was added. The reaction mixture was stirred at room temperature for 30 minutes. The mixture was poured into ice water and acidified with 6N hydrochloric acid and extracted with ethyl acetate. The organic layer was washed with water and brine, dried over magnesium sulfate and concentrated to give 1-(4-isobutyl-2-methoxyphenyl)pentanol (88 mg) as an oil.

후처리

  1. customCatalyst was removed by filtration
  2. concentrationthe filtrate was concentrated
  3. dissolutionThe residue was dissolved in methanol (5 ml)
  4. additionsodium borohydride (16 mg) was added
  5. stirringThe reaction mixture was stirred at room temperature for 30 minutes
  6. additionThe mixture was poured into ice water
  7. extractionextracted with ethyl acetate
  8. washThe organic layer was washed with water and brine
  9. dry with materialdried over magnesium sulfate
  10. concentrationconcentrated

출처 및 근거

ORD 기록
ord-4fe0070c9d9b4f1dbe277653f92ae6c5
출처 데이터셋
uspto-grants-1994_08
특허 번호
US05334716

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