Potassium Carbonate → HCID 10929467, 화합물

HRID 1741847노트

반응식

HRID 1741847 반응식
[OH:1][C:2]1[CH:26]=[CH:25][C:5]([C:6]([C:8]2[CH:9]=[C:10]([CH2:17][CH2:18][CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21])[N:11]3[C:16]=2[CH:15]=[CH:14][CH:13]=[CH:12]3)=[O:7])=[CH:4][CH:3]=1.Br[CH:28]([C:31]1[CH:36]=[CH:35][C:34]([CH2:37][CH:38]([CH3:40])[CH3:39])=[CH:33][CH:32]=1)[CH2:29][CH3:30].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[CH2:37]([C:34]1[CH:33]=[CH:32][C:31]([CH:28]([O:1][C:2]2[CH:3]=[CH:4][C:5]([C:6]([C:8]3[CH:9]=[C:10]([CH2:17][CH2:18][CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21])[N:11]4[C:16]=3[CH:15]=[CH:14][CH:13]=[CH:12]4)=[O:7])=[CH:25][CH:26]=2)[CH2:29][CH3:30])=[CH:36][CH:35]=1)[CH:38]([CH3:40])[CH3:39]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 10956141Benzene, 1-(1-bromopropyl)-4-(2-methylpropyl)-HCID 11824313Ethyl 4-[1-(4-hydroxybenzoyl)indolizin-3-yl]butyrate

생성물 1

HCID 10929467HCID 10929467, 화합물수율 87.7%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A mixture of ethyl 4-[1-(4-hydroxybenzoyl)indolizin-3-yl]butyrate (61 mg), 1-bromo-1-(4-isobutylphenyl)propane (53 mg) and potassium carbonate (72 mg) in N,N-dimethylformamide (2 ml) was stirred at room temperature for 18 hours. The reaction mixture was filtered and the filtrate was poured into a mixture of ethyl acetate and 0.5N hydrochloric acid. The organic layer was separated, washed with water and brine, dried over magnesium sulfate and evaporated. The residue was chromatographed on silica gel eluting with n-hexane and ethyl acetate (2:1) to give ethyl 4-[1-[4-[1-(4-isobutylphenyl)propyloxy]benzoyl]indolizin-3-yl]butyrate (80 mg) as an oil.

후처리

  1. filtrationThe reaction mixture was filtered
  2. additionthe filtrate was poured into a mixture of ethyl acetate and 0.5N hydrochloric acid
  3. customThe organic layer was separated
  4. washwashed with water and brine
  5. dry with materialdried over magnesium sulfate
  6. customevaporated
  7. customThe residue was chromatographed on silica gel eluting with n-hexane and ethyl acetate (2:1)

출처 및 근거

ORD 기록
ord-a80def6471c14d74aa6f4c5d7e62c1d6
출처 데이터셋
uspto-grants-1994_08
특허 번호
US05334716

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