Nitric Acid → 2-Nitro-5-(trifluoromethoxy)benzoic acid

HRID 1742

반응식

HRID 1742 반응식
[N+:1]([O-:4])(O)=[O:2].S(=O)(=O)(O)O.[F:10][C:11]([F:23])([F:22])[O:12][C:13]1[CH:14]=[C:15]([CH:19]=[CH:20][CH:21]=1)[C:16]([OH:18])=[O:17]>>[N+:1]([C:19]1[CH:20]=[CH:21][C:13]([O:12][C:11]([F:10])([F:23])[F:22])=[CH:14][C:15]=1[C:16]([OH:18])=[O:17])([O-:4])=[O:2]

참가 물질

4

반응물 3

HCID 944Nitric AcidHCID 1118Sulfuric AcidHCID 660963-(Trifluoromethoxy)benzoic acid

생성물 1

HCID 219046132-Nitro-5-(trifluoromethoxy)benzoic acid

실험 절차

29.7 ml of nitric acid were added dropwise to 76.5 ml of concentrated sulfuric acid, while cooling and stirring, and 9.0 g (43.7 mmol) of 3-trifluoromethoxybenzoic acid were then added. The reaction mixture was heated at 50°-55° C. for 1 hour and, after cooling, was poured onto ice, and the residue was filtered off with suction to give, after drying, 8.8 g of product, melting point 90°-93° C. (sintering at 85° C.).

후처리

  1. temperaturewhile cooling
  2. temperatureThe reaction mixture was heated at 50°-55° C. for 1 hour
  3. temperatureafter cooling
  4. additionwas poured onto ice
  5. filtrationthe residue was filtered off with suction
  6. customto give
  7. customafter drying
  8. custom8.8 g of product, melting point 90°-93° C. (sintering at 85° C.)

출처 및 근거

ORD 기록
ord-a19347c988eb4c1c9861adc66fd17858
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05726305

연결된 노트

불러오는 중…