Ethyl 4-amino-4-(3-methoxyphenyl)butanoate → 5-(3-Methoxyphenyl)-2-pyrrolidinone

HRID 1742227노트

반응식

HRID 1742227 반응식
[NH2:1][CH:2]([C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([O:16][CH3:17])[CH:11]=1)[CH2:3][CH2:4][C:5](OCC)=[O:6]>C1(C)C=CC=CC=1>[CH3:17][O:16][C:12]1[CH:11]=[C:10]([CH:2]2[NH:1][C:5](=[O:6])[CH2:4][CH2:3]2)[CH:15]=[CH:14][CH:13]=1

참가 물질

3

반응물 1

HCID 23361303Ethyl 4-amino-4-(3-methoxyphenyl)butanoate

생성물 1

HCID 152932255-(3-Methoxyphenyl)-2-pyrrolidinone수율 90%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

Ethyl 4-amino-4-(3-methoxyphenyl)butanoate (9.39 g) was dissolved in toluene (50 ml) and the solution heated under reflux for 0.5 hr to 1.0 hr. The mixture was cooled to ambient temperature, the precipitate was collected, and the filtrate was concentrated. The residue was recrystallized from ether to give 6.80 g (90%) of product, mp 84°-85° C.

후처리

  1. temperaturethe solution heated
  2. temperatureunder reflux for 0.5 hr to 1.0 hr
  3. customthe precipitate was collected
  4. concentrationthe filtrate was concentrated
  5. customThe residue was recrystallized from ether

출처 및 근거

ORD 기록
ord-5ca33221203749ca802052a2f23f4dd6
출처 데이터셋
uspto-grants-1994_08
특허 번호
US05338739

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