HCID 23365872, 화합물 → HCID 178497910, 화합물
반응식
C([O:8][C:9]1[C:17]2[C:12](=[CH:13][C:14]([NH:18][C:19](=[O:26])[CH2:20][CH:21]3[CH2:25][CH2:24][CH2:23][CH2:22]3)=[CH:15][CH:16]=2)[N:11]([CH2:27][C:28]2[CH:37]=[CH:36][C:31]([C:32]([O:34][CH3:35])=[O:33])=[CH:30][C:29]=2[O:38][CH3:39])[N:10]=1)C1C=CC=CC=1>C(OCC)(=O)C.[Pd]>[CH:21]1([CH2:20][C:19]([NH:18][C:14]2[CH:13]=[C:12]3[C:17]([C:9]([OH:8])=[N:10][N:11]3[CH2:27][C:28]3[CH:37]=[CH:36][C:31]([C:32]([O:34][CH3:35])=[O:33])=[CH:30][C:29]=3[O:38][CH3:39])=[CH:16][CH:15]=2)=[O:26])[CH2:22][CH2:23][CH2:24][CH2:25]1참가 물질
4
실험 절차
A mixture of methyl 4-[3-benzyloxy-6-(2-cyclopentylacetamido)indazol-1-ylmethyl]-3-methoxybenzoate (BB) (5.0 g.), and palladium-on-carbon (5% w/w, 1.25 g.), in ethyl acetate (190 ml.), was hydrogenated at 1.1 bar for 7.5 hours. The catalyst was removed by filtration through diatomaceous earth, washing the filter cake with ethanol, the filtrate partially evaporated, and the residue allowed to crystallize to give the title compound (2.56 g., 62%), as a solid, m.p. 242°-245° C.