Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzyl Alcohol → Benzyl anthranilate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzyl Alcohol | HCID 244 | — |
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Isatoic Anhydride | HCID 8359 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 촉매 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | Benzyl anthranilate | HCID 522771 | — |
반응 단계
A mixture of isatoic anhydride (8.54 g), benzyl alcohol (6.0 g), 4-dimethylaminopyridine (6.7 g), dimethylformamide (17 ml), triethylamine (5.28 g), and methylene chloride (160 ml) is refluxed overnight, diluted with an equal volume of ethyl acetate and washed with water, brine, and water. The organic solution is dried over magnesium sulfate, filtered, and concentrated in vacuo. The crude product is purified by flash chromatography eluting with 30% ethyl acetate in hexane to give the desired product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05340801 |
| 출처 데이터셋 | uspto-grants-1994_08 |
| ORD ID | ord-5b7fd9a50c3f42d58fe6793f43f34b9b |
| 출처 메모 | uspto-grants-1994_08 |