5-(Difluoromethyl)furan-2-carbaldehyde → 2-Furanmethanol, 5-(difluoromethyl)-alpha-ethynyl-

HRID 1742672노트

반응식

HRID 1742672 반응식
[C:1]([Mg]Br)#[CH:2].[F:5][CH:6]([F:14])[C:7]1[O:11][C:10]([CH:12]=[O:13])=[CH:9][CH:8]=1.OP([O-])(O)=O.[Na+]>O1CCCC1>[F:5][CH:6]([F:14])[C:7]1[O:11][C:10]([CH:12]([OH:13])[C:1]#[CH:2])=[CH:9][CH:8]=1

참가 물질

5

반응물 3

HCID 200796385-(Difluoromethyl)furan-2-carbaldehydeHCID 23672064Monosodium phosphateHCID 178418486HCID 178418486, 화합물

생성물 1

HCID 200796722-Furanmethanol, 5-(difluoromethyl)-alpha-ethynyl-

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

반응 조건

온도
0 °C

실험 절차

43 cm3 of a 0.5M solution of ethynyl magnesium bromide in tetrahydrofuran is added at 0° C. over one hour to a solution containing 2.5 g of the product prepared in Stage A and 30 cm3 of tetrahydrofuran. The reaction mixture is maintained under agitation at 0° C. for 1 hour. It is poured into a saturated aqueous solution of sodium acid phosphate. 3 g of product is obtained which is chromatographed on silica eluting with a hexane--ethyl acetate mixture (7-3). 2.5 g of desired product is obtained.

출처 및 근거

ORD 기록
ord-f2e40f6a9a4b4ce0a2aeb4da646cfc81
출처 데이터셋
uspto-grants-1994_08
특허 번호
US05340835

반응 노트

불러오는 중…