Water → 4-Chloro-6-(3-methylbut-1-oxy)-2-phenylpyrimidine

HRID 1742755

반응식

HRID 1742755 반응식
Cl[C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[N:3]=1.[OH2:15]>CC(C)CCO>[Cl:8][C:6]1[N:5]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[N:3]=[C:2]([O:15][CH2:11][CH2:10][CH:9]([CH3:14])[CH3:4])[CH:7]=1

참가 물질

4

반응물 2

HCID 962WaterHCID 77338Fenclorim

생성물 1

HCID 190067994-Chloro-6-(3-methylbut-1-oxy)-2-phenylpyrimidine

시약·촉매·용매 1

HCID 31260Isoamyl Alcohol용매2회

반응 조건

온도
25 °C

실험 절차

The reaction is carried out under an argon protective-gas atmosphere. A solution of 6.7 g (60.5 mmol) of sodium t-amylate in 50 ml of 3-methylbutanol is added dropwise to a solution, cooled to 0° C., of 12.4 g of 4,6-dichloro-2-phenylpyrimidine in 50 ml of 3-methylbutanol. The reaction mixture is allowed to warm to 25° C. overnight. Thin-layer chromatography shows the absence of starting material. The reaction mixture is poured into 180 ml of water and extracted three times with 80 ml of ethyl acetate. Combined organic phases are washed with water, dried using MgSO4 and filtered. Removal of the solvent gives 14.6 g (96% of theory) of the title compound.

후처리

  1. extractionextracted three times with 80 ml of ethyl acetate
  2. washCombined organic phases are washed with water
  3. customdried
  4. filtrationfiltered
  5. customRemoval of the solvent

출처 및 근거

ORD 기록
ord-4992921d69164201ae402c37e8c994ce
출처 데이터셋
uspto-grants-1994_08
특허 번호
US05340701

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