5-Amino-1-(2,4-difluorophenyl)-6,7,8-trifluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid → 5-Amino-7-[cis-3-amino-4-(1,2,3-triazol-1-yl)-pyrrolidin-1-yl]-1-(2,4-difluorophenyl)-6,8-difluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid

참여 물질

역할	이름	HCID	투입량
반응물	5-Amino-1-(2,4-difluorophenyl)-6,7,8-trifluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid	HCID 14896552	—
반응물	rac-(3R,4S)-4-(1H-1,2,3-triazol-1-yl)pyrrolidin-3-amine	HCID 70283180	—
생성물	5-Amino-7-[cis-3-amino-4-(1,2,3-triazol-1-yl)-pyrrolidin-1-yl]-1-(2,4-difluorophenyl)-6,8-difluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid	HCID 70282582	66%

반응 단계

Prepared by following the same procedure as described for Example 17 by using 5-amino-1-(2,4-difluorophenyl) -6,7,8-trifluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid and cis-3-amino-4-(1,2,3-triazol-1-yl)-pyrrolidine. Yield: 66%, m.p. 279°-281° C. 1H NMR (TFA) δ: 4.48-4.82 (m, 4H), 5.02 (m, 1H), 6.26 (m, 1H), 7.17 (m, 2H), 7.62 (m, 1H), 8.6 (s, 1H), 8.82 (d, 2H).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US05342846
출처 데이터셋	uspto-grants-1994_08
ORD ID	ord-393c0f69511f40e598d98e965662b115
출처 메모	uspto-grants-1994_08