Bromine → HCID 19006175, 화합물
반응식
[Br:1]Br.[Br:3][C:4]1[CH:5]=[C:6]([C:10]2[S:11][CH:12]=[CH:13][CH:14]=2)[CH:7]=[CH:8][CH:9]=1>C(O)(=O)C>[Br:1][C:12]1[S:11][C:10]([C:6]2[CH:7]=[CH:8][CH:9]=[C:4]([Br:3])[CH:5]=2)=[CH:14][CH:13]=1참가 물질
4
실험 절차
A solution of bromine (8 g; 50 mM) in 20 mL of glacial acetic acid was added dropwise to a vigorously stirred solution of 2-(3'-bromophenyl)thiophene (12 g; 50 mM) in 80 mL of glacial acetic acid. The resulting mixture was heated to reflux 5 hrs, cooled and poured onto ice. A solid separated which was filtered and washed with ice water, and purified on silica gel using hexane as solvent to give 68% of 2-bromo-5-[3'-bromophenyl]thiophene as an amorphous solid.
후처리
- temperatureThe resulting mixture was heated
- temperatureto reflux 5 hrs
- temperaturecooled
- additionpoured onto ice
- customA solid separated which
- filtrationwas filtered
- washwashed with ice water
- custompurified on silica gel
출처 및 근거
- ORD 기록
- ord-58f4f596d9034bc0adeb8c5d880c30c3
- 출처 데이터셋
- uspto-grants-1994_08
- 특허 번호
- US05342933
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