HCID 22238083, 화합물 → HCID 22238093, 화합물

HRID 1743387노트

반응식

HRID 1743387 반응식
[CH3:1][CH:2]1[CH2:10][C:9]2[C:4](=[C:5]([CH3:17])[C:6]([CH3:16])=[C:7]([O:11]CC(C)=C)[CH:8]=2)[N:3]1[CH:18]=[O:19]>C(N(CC)C1C=CC=CC=1)C.C(OCC)C>[OH:11][C:7]1[C:8]([CH2:6][C:5]([CH3:17])=[CH2:4])=[C:9]2[C:4](=[C:5]([CH3:17])[C:6]=1[CH3:16])[N:3]([CH:18]=[O:19])[CH:2]([CH3:1])[CH2:10]2

참가 물질

4

반응물 1

HCID 22238083HCID 22238083, 화합물

생성물 1

HCID 22238093HCID 22238093, 화합물수율 137.5%

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 7061N,N-Diethylaniline용매

실험 절차

A solution of 2,3-dihydro-2,6,7-trimethyl-5-[(2-methyl-2-propenyl)oxy]-1H-indole-1-carbaldehyde (0.59 g, 2.3 mmol) in N,N-diethylaniline (3 mL) was stirred at 200° C. for 4.5 hours under the nitrogen atmosphere. The reaction mixture was dissolved in diethyl ether, washed with 1N hydrochloric acid, water and saturated brine, dried over magnesium sulfate, filtered, and concentrated under reduced pressure. The residue was recrystallized from ethyl acetate-diisopropyl ether to obtain 0.41 g of the title compound.

후처리

  1. washwashed with 1N hydrochloric acid, water and saturated brine
  2. dry with materialdried over magnesium sulfate
  3. filtrationfiltered
  4. concentrationconcentrated under reduced pressure
  5. customThe residue was recrystallized from ethyl acetate-diisopropyl ether

출처 및 근거

ORD 기록
ord-77f338ef10fd4377b99ae318e88d33c2
출처 데이터셋
uspto-grants-2006_03
특허 번호
US07008940B1

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