Ammonium Hydroxide → 4-{[(2R)-3-Amino-2-hydroxypropyl]oxy}benzonitrile

HRID 1743732노트

반응식

HRID 1743732 반응식
[O:1]1[CH2:3][C@@H:2]1[CH2:4][O:5][C:6]1[CH:13]=[CH:12][C:9]([C:10]#[N:11])=[CH:8][CH:7]=1.[NH4+:14].[OH-]>C(O)(C)C>[NH2:14][CH2:3][C@@H:2]([OH:1])[CH2:4][O:5][C:6]1[CH:13]=[CH:12][C:9]([C:10]#[N:11])=[CH:8][CH:7]=1

참가 물질

4

반응물 2

HCID 14923Ammonium HydroxideHCID 6934186(R)-4-(Oxiran-2-ylmethoxy)benzonitrile

생성물 1

HCID 300720964-{[(2R)-3-Amino-2-hydroxypropyl]oxy}benzonitrile수율 91%

시약·촉매·용매 1

HCID 3776Isopropanol용매

실험 절차

4-[(2R)-Oxiranylmethoxy]benzonitrile (14.65 g, 83.6 mmol; prepared as described in international patent application WO 99/31100) was mixed with conc. NH4OH (64 mL) and 87 mL of isopropanol. The mixture was stirred at r.t for 18 h. The reaction mixture was filtered and the filtrate evaporated to give 14.6 g (91%) of the sub-title compound.

후처리

  1. filtrationThe reaction mixture was filtered
  2. customthe filtrate evaporated

출처 및 근거

ORD 기록
ord-2898c09fcc9b474dbeffd4f6f392d00f
출처 데이터셋
uspto-grants-2006_03
특허 번호
US07012074B2

반응 노트

불러오는 중…