Nitromethane → HCID 22236902, 화합물
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[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]([CH3:14])=[CH:8][C:9]([O:11][CH2:12][CH3:13])=[O:10].[N+:15]([CH3:18])([O-:17])=[O:16].C1CCN2C(=NCCC2)CC1>C(#N)C>[CH3:14][C:7]([C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=1)([CH2:18][N+:15]([O-:17])=[O:16])[CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10]참가 물질
5
실험 절차
A solution of 6 g of the compound obtained in Step 1, 3.36 ml of nitromethane and 4.26 ml of DBU dissolved in 120 ml of acetonitrile was heated to reflux for 36 hours. After the reaction was completed, the reaction solution was distilled under reduced pressure. The residue thus obtained was purified by a silica gel column chromatography using a mixture of ethyl acetate and n-hexane of 1:9 to obtain 1.8 g of the title compound as a syrup.
후처리
- temperaturewas heated
- temperatureto reflux for 36 hours
- distillationthe reaction solution was distilled under reduced pressure
- customThe residue thus obtained
- customwas purified by a silica gel column chromatography
- additiona mixture of ethyl acetate and n-hexane of 1:9
출처 및 근거
- ORD 기록
- ord-995470827d67461cbbf0be5af4c91273
- 출처 데이터셋
- uspto-grants-2006_03
- 특허 번호
- US07012144B2
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