Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Quinaldic Acid → 3-Benzyloxy-6-(2-propyloxy)quinoline-2-carboxylic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Quinaldic Acid | HCID 7124 | — |
| 반응물 | 1-Hydroxybenzotriazole | HCID 75771 | — |
| 반응물 | O-benzylglycine toluene-p-sulphonate | HCID 6451311 | — |
| 반응물 | Ethylacetate heptane | HCID 21899848 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 3-Benzyloxy-6-(2-propyloxy)quinoline-2-carboxylic acid | HCID 53779731 | 129.7% |
반응 단계
2.7 g (8 mmol) of the above quinolinecarboxylic acid were reacted with 2.7 g (8 mmol) of glycine benzyl ester tosylate, 4.4 ml (32 mmol) of NEM, 1.35 g (10 mmol) of HOBT and 3.6 g (8.8 mmol) of CMC in 300 ml of anhydrous methylene chloride at 20° C. for 24 hours, analogously to Example 25g). After working up and chromatography over silica gel with n-heptane/ethyl acetate (3:2), 3.5 g of oily product were obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05726305 |
| 출처 데이터셋 | uspto-grants-1998_03 |
| ORD ID | ord-dd95acbc02174382a8fb617b567ae3bb |
| 출처 메모 | uspto-grants-1998_03 |