Acetone → 4-Thiazolidinecarboxamide, 2,2,5,5-tetramethyl-

HRID 1744198노트

반응식

HRID 1744198 반응식
[NH2:1][C@H:2]([C:7]([NH2:9])=[O:8])[C:3]([SH:6])([CH3:5])[CH3:4].[CH3:10][C:11]([CH3:13])=O>O>[CH3:10][C:11]1([CH3:13])[NH:1][CH:2]([C:7]([NH2:9])=[O:8])[C:3]([CH3:5])([CH3:4])[S:6]1

참가 물질

4

반응물 2

HCID 180AcetoneHCID 22797962HCID 22797962, 화합물

생성물 1

HCID 101713024-Thiazolidinecarboxamide, 2,2,5,5-tetramethyl-수율 92%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Penicillaminamide (74.0 g, 0.50 mol) was dissolved in distilled water (800 ml) and added with acetone (58.0 g, 1.00 mol). The mixture was allowed to react at 30° C. for 1 hour with stirring under normal pressure and cooled. Then, water and acetone were evaporated by using an evaporator. The residue was washed with acetone to obtain white crystals (86.5 g, 0.46 mol) of 2,2,5,5-tetramethyl-1,3-thiazolidine-4-carboxylic acid amide. The yield to penicillaminamide was 92.0 mole %.

후처리

  1. customto react at 30° C. for 1 hour
  2. temperaturecooled
  3. customThen, water and acetone were evaporated
  4. customan evaporator
  5. washThe residue was washed with acetone

출처 및 근거

ORD 기록
ord-7cc397e97fa94300a9b9a914ee20807c
출처 데이터셋
uspto-grants-2006_03
특허 번호
US07015029B2

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