참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Dibenz(b,f)azepine | HCID 9212 | — |
| 반응물 | Sodium Cyanate | HCID 517096 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | Carbamazepine | HCID 2554 | 80.3% |
반응 단계
30 g iminostilbene are heated to 60° C. in 360 ml acetic acid and 50 ml ethanol, and 20 g 98% sodium cyanate is added within 1.5 hours at this temperature. After a short heating to 80° C., the mixture is further stirred at 60° C., and then cooled to 15° C., sucked off, washed with 20 l acetic acid and dried to yield 29.4 g (80.3% of theoretical) of carbamazepine, having a melting point of 189° C. to 192° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07015322B1 |
|---|
| 출처 데이터셋 | uspto-grants-2006_03 |
|---|
| ORD ID | ord-25819033458c4515bfe6d3a3aa574b2d |
|---|
| 출처 메모 | uspto-grants-2006_03 |
|---|
