홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Triethylsilane → 3-[4-(2-Aminoethoxy)phenyl]-2-ethoxypropionic acid ethyl ester

HRID 1744456
노트
인쇄 미리보기

반응식

HRID 1744456 반응식
[CH2:1]([O:3][C:4](=[O:28])[CH:5]([O:25][CH2:26][CH3:27])[CH:6]([C:8]1[CH:13]=[CH:12][C:11]([O:14][CH2:15][CH2:16][NH:17]C(OC(C)(C)C)=O)=[CH:10][CH:9]=1)O)[CH3:2].C([SiH](CC)CC)C>FC(F)(F)C(O)=O.C(OCC)(=O)C>[CH2:1]([O:3][C:4](=[O:28])[CH:5]([O:25][CH2:26][CH3:27])[CH2:6][C:8]1[CH:13]=[CH:12][C:11]([O:14][CH2:15][CH2:16][NH2:17])=[CH:10][CH:9]=1)[CH3:2]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 2

HCID 12052TriethylsilaneHCID 696255813-[4-(2-Tert-butoxycarbonylaminoethoxy)phenyl]-2-ethoxy-3-hydroxypropionic acid ethyl ester

생성물 1

HCID 108589313-[4-(2-Aminoethoxy)phenyl]-2-ethoxypropionic acid ethyl ester수율 73.9%

시약·촉매·용매 2

HCID 6422Trifluoroacetic acid용매HCID 8857Ethyl Acetate용매

실험 절차

The compound obtained in Step b (53.7 mg) was dissolved in trifluoroacetic acid (2 ml), added with triethylsilane (0.4 ml, Aldrich) and stirred at room temperature for 2.5 days. The reaction mixture was diluted with ethyl acetate, washed successively with saturated aqueous sodium hydrogencarbonate and saturated brine, dried over magnesium sulfate and concentrated. The resulting residue was applied on a silica gel column and eluted with chloroform/methanol (10:1) to obtain the title compound (28.1 mg).

후처리

  1. washwashed successively with saturated aqueous sodium hydrogencarbonate and saturated brine
  2. dry with materialdried over magnesium sulfate
  3. concentrationconcentrated
  4. washeluted with chloroform/methanol (10:1)

출처 및 근거

ORD 기록
ord-9af7608ca2534abc877ee964af2b0668
출처 데이터셋
uspto-grants-2006_03
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07015345B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트