1-(4-fluorophenyl)-5-methyl-1H-pyrazole-4-carboxylic acid → N-(3-Cyano-4-pyrrolidinophenyl)-1-(4-fluorophenyl)-5-methylpyrazole-4-carboxamide

HRID 1744614노트

반응식

HRID 1744614 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([CH3:13])=[C:11]([C:14]([OH:16])=O)[CH:10]=[N:9]2)=[CH:4][CH:3]=1.[NH2:17][C:18]1[CH:19]=[CH:20][C:21]([N:26]2[CH2:30][CH2:29][CH2:28][CH2:27]2)=[C:22]([CH:25]=1)[C:23]#[N:24]>>[C:23]([C:22]1[CH:25]=[C:18]([NH:17][C:14]([C:11]2[CH:10]=[N:9][N:8]([C:5]3[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=3)[C:12]=2[CH3:13])=[O:16])[CH:19]=[CH:20][C:21]=1[N:26]1[CH2:30][CH2:29][CH2:28][CH2:27]1)#[N:24]

참가 물질

3

반응물 2

HCID 42702631-(4-fluorophenyl)-5-methyl-1H-pyrazole-4-carboxylic acidHCID 107500875-Amino-2-(pyrrolidin-1-yl)benzonitrile

생성물 1

HCID 22228145N-(3-Cyano-4-pyrrolidinophenyl)-1-(4-fluorophenyl)-5-methylpyrazole-4-carboxamide수율 48.1%

실험 절차

By the reaction and treatment in the same manner as in Example 64 using 1-(4-fluorophenyl)-5-methylpyrazole-4-carboxylic acid (1.2 g) and 5-amino-2-pyrrolidinobenzonitrile (0.8 g), the title compound (0.8 g) was obtained, melting point: 185° C.

출처 및 근거

ORD 기록
ord-3ce1e9227d354bdebcf1d1e583c5a18f
출처 데이터셋
uspto-grants-2006_03
특허 번호
US07015218B1

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