1-(4-chlorophenyl)-5-methyl-1H-pyrazole-4-carbonyl chloride → HCID 22228187, 화합물

HRID 1744655노트

반응식

HRID 1744655 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([CH3:13])=[C:11]([C:14](Cl)=[O:15])[CH:10]=[N:9]2)=[CH:4][CH:3]=1.[NH2:17][C:18]1[CH:19]=[CH:20][C:21]([N:26]2[CH2:31][CH2:30][CH:29]([O:32][CH2:33][CH2:34][O:35][CH3:36])[CH2:28][CH2:27]2)=[C:22]([CH:25]=1)[C:23]#[N:24]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([CH3:13])=[C:11]([C:14]([NH:17][C:18]3[CH:19]=[CH:20][C:21]([N:26]4[CH2:31][CH2:30][CH:29]([O:32][CH2:33][CH2:34][O:35][CH3:36])[CH2:28][CH2:27]4)=[C:22]([C:23]#[N:24])[CH:25]=3)=[O:15])[CH:10]=[N:9]2)=[CH:4][CH:3]=1

참가 물질

3

반응물 2

HCID 27761281-(4-chlorophenyl)-5-methyl-1H-pyrazole-4-carbonyl chlorideHCID 22228028HCID 22228028, 화합물

생성물 1

HCID 22228187HCID 22228187, 화합물수율 19.9%

실험 절차

By the reaction and treatment in the same manner as in Example 150 using 1-(4-chlorophenyl)-5-methylpyrazole-4-carboxylic chloride (0.13 g) and 5-amino-2-[4-(2-methoxyethoxy)piperidin-1-yl]benzonitrile (0.14 g), the title compound (0.05 g) was obtained, melting point: 180–182° C.

출처 및 근거

ORD 기록
ord-a67c1fff4825446f9dd9e806805dcfb9
출처 데이터셋
uspto-grants-2006_03
특허 번호
US07015218B1

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