4-Chloro-3-Fluorobenzaldehyde → 1-(4-Chloro-3-fluorophenyl)ethan-1-ol

HRID 1744876노트

반응식

HRID 1744876 반응식
[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][C:3]=1[F:10].[CH3:11]COCC.C[Mg+].[Br-]>C1COCC1>[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]([OH:7])[CH3:11])=[CH:4][C:3]=1[F:10]

참가 물질

4

반응물 2

HCID 27249854-Chloro-3-FluorobenzaldehydeHCID 178467672HCID 178467672, 화합물

생성물 1

HCID 219347441-(4-Chloro-3-fluorophenyl)ethan-1-ol

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
-50 °C

실험 절차

To a solution of 4-chloro-3-fluorobenzaldehyde (1 eq) in THF (0.3 M) at −78° C. was added 3M/Et2O MeMgBr (1.5 eq). The reaction mixture was stirred at −50° C. for 3 hrs, quenched with aqueous saturated NH4Cl and extracted with EtOAc. The combined organic layers were dried over Na2SO4 and concentrated to give 1-(4-chloro-3-fluorophenyl)ethanol, which was used as such for the next step.

후처리

  1. customquenched with aqueous saturated NH4Cl
  2. extractionextracted with EtOAc
  3. dry with materialThe combined organic layers were dried over Na2SO4
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-fe10e2668635412bb68af3e8a73e6205
출처 데이터셋
uspto-grants-2006_03
특허 번호
US07019022B2

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