Benzo(d)thiazol-2-amine → ethyl imidazo[2,1-b][1,3]benzothiazole-2-carboxylate

HRID 1744916노트

반응식

HRID 1744916 반응식
Br[CH2:2][C:3](=O)[C:4]([O:6][CH2:7][CH3:8])=[O:5].[NH2:10][C:11]1[S:12][C:13]2[CH:19]=[CH:18][CH:17]=[CH:16][C:14]=2[N:15]=1>CN(C=O)C>[N:10]1[C:3]([C:4]([O:6][CH2:7][CH3:8])=[O:5])=[CH:2][N:15]2[C:14]3[CH:16]=[CH:17][CH:18]=[CH:19][C:13]=3[S:12][C:11]=12

참가 물질

4

반응물 2

HCID 8706Benzo(d)thiazol-2-amineHCID 66144Ethyl bromopyruvate

생성물 1

HCID 1480574ethyl imidazo[2,1-b][1,3]benzothiazole-2-carboxylate

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Ethyl bromopyruvate (9.8 g, 50 mmol) was added dropwise to a stirred solution of 2-aminobenzothiazole (7.5 g, 50 mmol) in DMF (100 ml) at room temperature. After the addition, the reaction mixture was heated to reflux for 6 h. The reaction mixture was cooled to room temperature and quenched with ice cold water. The aqueous layer was neutralized with NH4OH and the separated solid was fitered. It was washed well with water and dried. The crude product obtained was taken to next step without purification.

후처리

  1. additionAfter the addition
  2. temperaturethe reaction mixture was heated
  3. temperatureto reflux for 6 h
  4. customquenched with ice cold water
  5. washIt was washed well with water
  6. customdried

출처 및 근거

ORD 기록
ord-63045a7327d34c5ca9b00b633ef3bf54
출처 데이터셋
uspto-grants-2006_03
특허 번호
US07018997B2

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