Phenylboronic Acid → N-(3-Nitro[1,1'-biphenyl]-4-yl)carbamic Acid tert-Butyl Ester

HRID 1745438

반응식

HRID 1745438 반응식
[C:1]([O:5][C:6](=[O:18])[NH:7][C:8]1[CH:13]=[CH:12][C:11](I)=[CH:10][C:9]=1[N+:15]([O-:17])=[O:16])([CH3:4])([CH3:3])[CH3:2].[C:19]1(B(O)O)[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>>[C:1]([O:5][C:6](=[O:18])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[CH:10][C:9]=1[N+:15]([O-:17])=[O:16])([CH3:4])([CH3:3])[CH3:2]

참가 물질

3

반응물 2

HCID 66827Phenylboronic AcidHCID 23554339Tert-butyl (4-iodo-2-nitrophenyl)carbamate

생성물 1

HCID 57745588N-(3-Nitro[1,1'-biphenyl]-4-yl)carbamic Acid tert-Butyl Ester수율 93.2%

실험 절차

Prepared from (4-iodo-2-nitro-phenyl)-carbamic acid tert.-butyl ester (Example A1) (994 mg, 2.73 mmol) and phenyl boronic acid (576 mg, 3.00 mmol) according to the general procedure B. Obtained as a bright yellow solid (800 mg).

출처 및 근거

ORD 기록
ord-b9b84a0a3a404673b64ceb7de1a0a1a9
출처 데이터셋
uspto-grants-2006_03
특허 번호
US07018998B2

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