2-Bromothiazole → (2-Nitro-4-thiazol-2-yl-phenyl)-carbamic acid tert.-butyl ester

반응식

[C:1]([O:5][C:6](=[O:30])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([Sn](CCCC)(CCCC)CCCC)=[CH:10][C:9]=1[N+:27]([O-:29])=[O:28])([CH3:4])([CH3:3])[CH3:2].Br[C:32]1[S:33][CH:34]=[CH:35][N:36]=1>>[C:1]([O:5][C:6](=[O:30])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:32]2[S:33][CH:34]=[CH:35][N:36]=2)=[CH:10][C:9]=1[N+:27]([O-:29])=[O:28])([CH3:2])([CH3:3])[CH3:4]

참가 물질

반응물 2

HCID 764302-Bromothiazole

HCID 23554337(2-Nitro-4-tributylstannanyl-phenyl)-carbamic acid tert.-butyl ester

생성물 1

HCID 69592824(2-Nitro-4-thiazol-2-yl-phenyl)-carbamic acid tert.-butyl ester수율 26.2%

실험 절차

Prepared from (2-nitro-4-tributylstannanyl-phenyl)-carbamic acid tert.-butyl ester (Example D2) (1.0 g, 1.9 mmol) and 2-bromothiazole (0.56 mL, 6.27 mmol) according to the general procedure E. Obtained as a yellow solid (160 mg). MS (EI) 321 (M+).

출처 및 근거

ORD 기록: ord-f8b84082738d4558b2254138372f388d
출처 데이터셋: uspto-grants-2006_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07018998B2

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