2-Benzyloxy-5-trimethylstannyl-pyridine → [4-(6-Benzyloxy-pyridin-3-yl)-2-nitro-phenyl]-carbamic acid tert.-butyl ester

HRID 1745468노트

반응식

HRID 1745468 반응식
[C:1]([O:5][C:6](=[O:18])[NH:7][C:8]1[CH:13]=[CH:12][C:11](I)=[CH:10][C:9]=1[N+:15]([O-:17])=[O:16])([CH3:4])([CH3:3])[CH3:2].[C:19]1([CH2:25][O:26][C:27]2[CH:32]=[CH:31][C:30]([Sn](C)(C)C)=[CH:29][N:28]=2)[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>>[C:1]([O:5][C:6](=[O:18])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:30]2[CH:29]=[N:28][C:27]([O:26][CH2:25][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)=[CH:32][CH:31]=2)=[CH:10][C:9]=1[N+:15]([O-:17])=[O:16])([CH3:4])([CH3:3])[CH3:2]

참가 물질

3

반응물 2

HCID 222247412-Benzyloxy-5-trimethylstannyl-pyridineHCID 23554339Tert-butyl (4-iodo-2-nitrophenyl)carbamate

생성물 1

HCID 69592778[4-(6-Benzyloxy-pyridin-3-yl)-2-nitro-phenyl]-carbamic acid tert.-butyl ester수율 103.9%

실험 절차

Prepared from (4-iodo-2-nitro-phenyl)-carbamic acid tert.-butyl ester (Example A1) (728 mg, 2.0 mmol) and 2-(phenylmethoxy)-5-(trimethylstannyl)-pyridine (766 mg, 2.2 mmol) [CAS-No. [188881-22-3], WO 9709311] according to the general procedure E. Obtained as a yellow solid (876 mg).

출처 및 근거

ORD 기록
ord-b5411286f7b14b83b76340683c8f0af0
출처 데이터셋
uspto-grants-2006_03
특허 번호
US07018998B2

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