Ethyl 2-imidazol-1-yl-thiazole-4-carboxylate → 3-(2-Imidazol-1-yl-thiazol-4-yl)-3-oxo-propionic acid tert.-butyl ester

HRID 1745544노트

반응식

HRID 1745544 반응식
[N:1]1([C:6]2[S:7][CH:8]=[C:9]([C:11]([O:13]CC)=O)[N:10]=2)[CH:5]=[CH:4][N:3]=[CH:2]1.[C:16]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])(=[O:18])[CH3:17].[Li]>>[C:20]([O:19][C:16](=[O:18])[CH2:17][C:11]([C:9]1[N:10]=[C:6]([N:1]2[CH:5]=[CH:4][N:3]=[CH:2]2)[S:7][CH:8]=1)=[O:13])([CH3:23])([CH3:22])[CH3:21]

참가 물질

3

반응물 2

HCID 22224610Ethyl 2-imidazol-1-yl-thiazole-4-carboxylateHCID 86586795Lithium Tert-butyl Acetate

생성물 1

HCID 695927683-(2-Imidazol-1-yl-thiazol-4-yl)-3-oxo-propionic acid tert.-butyl ester

실험 절차

Prepared from ethyl 2-imidazol-1-yl-thiazole-4-carboxylate [CAS-No. 256420-32-3] by treatment with lithium tert.-butyl acetate according to general procedure H (method b). Obtained as an orange oil (12.0 g).

출처 및 근거

ORD 기록
ord-422347eab7e64b2f84c8e111a3eca5aa
출처 데이터셋
uspto-grants-2006_03
특허 번호
US07018998B2

반응 노트

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