3-Bromo-1,2-oxazole → 1-(4,5-dihydroisoxazol-3-yl)-1H-1,2,4-triazole-3-carboxylic acid

반응식

Br[C:2]1[CH:6]=[CH:5][O:4][N:3]=1.C[O:8][C:9]([C:11]1[N:15]=[CH:14][NH:13][N:12]=1)=[O:10]>>[O:4]1[CH2:5][CH2:6][C:2]([N:13]2[CH:14]=[N:15][C:11]([C:9]([OH:10])=[O:8])=[N:12]2)=[N:3]1

참가 물질

반응물 2

HCID 139338913-Bromo-1,2-oxazole

HCID 178499122HCID 178499122, 화합물

생성물 1

HCID 866505651-(4,5-dihydroisoxazol-3-yl)-1H-1,2,4-triazole-3-carboxylic acid

실험 절차

1-(4,5-dihydroisoxazol-3-yl)-1H-1,2,4-triazole-3-carboxylic acid I-171a and I-171b were prepared using the analogous procedure to Example 35 except that racemic compound I-75 was used as the starting bromo-isoxazole and 1H-1,2,4-triazole-3-carboxylic acid methyl ester as the nucleophile Additionally, at some point during the course of the reaction or workup, the ester hydrolyzed to the corresponding acid. These compounds can be separated using chiral HPLC methods known in the art. For example, see chiral HPLC Method disclosed herein. [M−H]−=356.6 m/z. Activity: C

후처리

customduring the course of the reaction or workup
customThese compounds can be separated

출처 및 근거

ORD 기록: ord-7adede485c544c839a26c6e1342f94cb
출처 데이터셋: uspto-grants-2015_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09149465B2

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