4-(Trifluoromethyl)phenylboronic acid → HCID 178498924, 화합물

HRID 1746192노트

반응식

HRID 1746192 반응식
[CH3:1][O:2][C:3]([C:5]1[C:6](=[O:17])[S:7][C:8]2[C:13]([C:14]=1[OH:15])=[CH:12][CH:11]=[C:10](Br)[CH:9]=2)=[O:4].[F:18][C:19]([F:30])([F:29])[C:20]1[CH:25]=[CH:24][C:23](B(O)O)=[CH:22][CH:21]=1>>[CH3:1][O:2][C:3]([C:5]1[C:6](=[O:17])[S:7][C:8]2[C:13]([C:14]=1[OH:15])=[CH:12][CH:11]=[C:10]([C:23]1[CH:24]=[CH:25][C:20]([C:19]([F:30])([F:29])[F:18])=[CH:21][CH:22]=1)[CH:9]=2)=[O:4]

참가 물질

3

반응물 2

HCID 27343894-(Trifluoromethyl)phenylboronic acidHCID 178498916HCID 178498916, 화합물

생성물 1

HCID 178498924HCID 178498924, 화합물

실험 절차

4-Hydroxy-2-oxo-7-(4-trifluoromethyl-phenyl)-2H-thiochromene-3-carboxylic acid methyl ester was prepared from 7-bromo-4-hydroxy-2-oxo-2H-thiochromene-3-carboxylic acid methyl ester (Example 5 e) and 4-trifluoromethylphenylboronic acid under conditions analogous to Example 7(a). MS ESI(−) m/e: 379.05 (M−1).

출처 및 근거

ORD 기록
ord-3fec784a43234f959c2163b42e6181e9
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09149476B2

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