Z-O-tert-butyl-L-serine N-hydroxysuccinimide ester → HCID 178423965, 화합물

HRID 1746303

반응식

HRID 1746303 반응식
[CH3:1]C1C=CC=C2C=1C(=O)N(C1C=CC=CC=1)C(C(NC1N=CN=C3C=1N=CN3)CC)=N2.O=C1CCC(=O)N1OC(=O)C(NC([O:51][CH2:52][C:53]1[CH:58]=[CH:57][CH:56]=[CH:55][CH:54]=1)=O)COC(C)(C)C.O=C1CCC(=O)N1OC(=O)C(NC(OCC1C=CC=CC=1)=O)CC.NC1N=C2C(NC=N2)=C(Br)N=1.BrC1N=CN=C2C=1NC=N2.[NH2:105][C:106]1[N:114]=[C:113]2[C:109]([N:110]=[CH:111][NH:112]2)=[C:108]([NH:115][CH:116]([C:123]2[N:132](C3C=CC=CC=3)C(=O)[C:130]3[C:125](=[CH:126][CH:127]=[CH:128][C:129]=3C)[N:124]=2)[CH2:117][O:118]C(C)(C)C)[N:107]=1>FC(F)(F)C(O)=O>[NH2:105][C:106]1[N:114]=[C:113]2[C:109]([N:110]=[CH:111][NH:112]2)=[C:108]([NH:115][CH:116]([C:123]2[N:124]([C:125]3[CH:130]=[CH:129][CH:128]=[CH:127][CH:126]=3)[C:52](=[O:51])[C:53]3[C:54](=[CH:55][CH:56]=[CH:57][C:58]=3[CH3:1])[N:132]=2)[CH2:117][OH:118])[N:107]=1

참가 물질

8

반응물 6

HCID 2729196Z-O-tert-butyl-L-serine N-hydroxysuccinimide esterHCID 5287830Purine, 6-bromo-HCID 61011392-Amino-6-bromopurineHCID 12961228(2,5-Dioxopyrrolidin-1-yl) 2-(phenylmethoxycarbonylamino)butanoateHCID 178423963HCID 178423963, 화합물HCID 178456854HCID 178456854, 화합물

생성물 1

HCID 178423965HCID 178423965, 화합물

시약·촉매·용매 1

HCID 6422Trifluoroacetic acid용매

실험 절차

Compound 68 was prepared using the general procedure described above with respect to compound 14, but 2-benzyloxycarbonylamino-3-tert-butoxy-propionic acid 2,5-dioxo-pyrrolidin-1-yl ester was substituted for 2-benzyloxycarbonylaminobutyric acid 2,5-dioxo-pyrrolidin-1-yl ester in step B, and 2-amino-6-bromopurine was substituted for 6-bromopurine in step D. The obtained 2-[1-(2-amino-9H-purin-6-ylamino)-2-tert-butoxy-ethyl]-5-methyl-3-phenyl-3H-quinazolin-4-one was then dissolved in trifluoroacetic acid and allowed to stir at ambient temperature for 5 hours. Purification by LC provided the product 68 as a white solid. MS (ES): m/z 429 (M+H), 215, 206, 151. Compound 68 is shown below.

후처리

  1. customCompound 68 was prepared
  2. customPurification by LC

출처 및 근거

ORD 기록
ord-0cd03cdbc17f480da66b62c1e16b9c0a
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09149477B2

연결된 노트

불러오는 중…