3-(3-methoxy-phenyl)-5-methyl-2-{1-[9-(2-trimethylsilanyl-ethoxymethyl)-9H-purin-6-ylamino]-ethyl}-3H-quinazolin-4-one → HCID 178490792, 화합물

HRID 1746314노트

반응식

HRID 1746314 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([N:9]2[C:18](=[O:19])[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][C:16]=3[CH3:20])[N:11]=[C:10]2[CH:21]([NH:23][C:24]2[N:32]=[CH:31][N:30]=[C:29]3[C:25]=2[N:26]=[CH:27][N:28]3COCC[Si](C)(C)C)[CH3:22])[CH:6]=[CH:7][CH:8]=1.OC1C=C(N2C(=O)C3C(=CC=CC=3C)N=C2C(NC2N=CN=C3C=2N=CN3)C)C=CC=1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([N:9]2[C:18](=[O:19])[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][C:16]=3[CH3:20])[N:11]=[C:10]2[CH:21]([NH:23][C:24]2[N:32]=[CH:31][N:30]=[C:29]3[C:25]=2[N:26]=[CH:27][NH:28]3)[CH3:22])[CH:6]=[CH:7][CH:8]=1

참가 물질

3

반응물 2

HCID 666640533-(3-methoxy-phenyl)-5-methyl-2-{1-[9-(2-trimethylsilanyl-ethoxymethyl)-9H-purin-6-ylamino]-ethyl}-3H-quinazolin-4-oneHCID 1784239553-(3-hydroxy-phenyl)-5-methyl-2-[1-(9H-purin-6-ylamino)-ethyl]-3H-quinazolin-4-one

생성물 1

HCID 178490792HCID 178490792, 화합물

실험 절차

Compound 127 was reacted in accordance with the procedure described above for compound 121 (step D) to provide compound 128. m/z=428 (M+H). The structure of compound 128 is shown below.

출처 및 근거

ORD 기록
ord-e71e6d5d20d24a56a9045001882ae6df
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09149477B2

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