Isopropanol → Isopropyl chloro(oxo)acetate

HRID 1746368노트

반응식

[CH:1]([OH:4])([CH3:3])[CH3:2].[C:5](Cl)(=[O:9])[C:6]([Cl:8])=[O:7]>>[CH:1]([O:4][C:5](=[O:9])[C:6]([Cl:8])=[O:7])([CH3:3])[CH3:2]

참가 물질

반응물 2

HCID 3776Isopropanol

HCID 65578Oxalyl chloride

생성물 1

HCID 11355577Isopropyl chloro(oxo)acetate

실험 절차

Isopropanol (158 μL, 2.1 mmol, 1.0 eq.) was added dropwise over 5 minutes to oxalyl chloride (350 μL, 4.14 mmol 2.0 eq.) at 0° C., and the resulting mixture was stirred at room temperature for 2 hours. The excess oxalyl chloride was removed by rotary evaporation (40° C., 50 mmHg) and used without further purification.

후처리

customThe excess oxalyl chloride was removed by rotary evaporation (40° C., 50 mmHg)
customused without further purification

출처 및 근거

ORD 기록: ord-be619ae36cb54eea93d80fef38e114f4
출처 데이터셋: uspto-grants-2015_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09150500B2

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