4-((3,5-Dimethylisoxazol-4-yl)methoxy)benzene-1-sulfonyl chloride → 4-((3,5-dimethylisoxazol-4-yl)methoxy)-N-(4-ethylphenyl)-N-isobutylbenzenesulfonamide

HRID 1746421노트

반응식

HRID 1746421 반응식
[CH2:1]([C:3]1[CH:13]=[CH:12][C:6]([NH:7][CH2:8][CH:9]([CH3:11])[CH3:10])=[CH:5][CH:4]=1)[CH3:2].[CH3:14][C:15]1[C:19]([CH2:20][O:21][C:22]2[CH:27]=[CH:26][C:25]([S:28](Cl)(=[O:30])=[O:29])=[CH:24][CH:23]=2)=[C:18]([CH3:32])[O:17][N:16]=1>N1C=CC=CC=1>[CH3:14][C:15]1[C:19]([CH2:20][O:21][C:22]2[CH:23]=[CH:24][C:25]([S:28]([N:7]([C:6]3[CH:12]=[CH:13][C:3]([CH2:1][CH3:2])=[CH:4][CH:5]=3)[CH2:8][CH:9]([CH3:10])[CH3:11])(=[O:30])=[O:29])=[CH:26][CH:27]=2)=[C:18]([CH3:32])[O:17][N:16]=1

참가 물질

4

반응물 2

HCID 164907024-((3,5-Dimethylisoxazol-4-yl)methoxy)benzene-1-sulfonyl chlorideHCID 284793854-ethyl-N-(2-methylpropyl)aniline

생성물 1

HCID 715434874-((3,5-dimethylisoxazol-4-yl)methoxy)-N-(4-ethylphenyl)-N-isobutylbenzenesulfonamide수율 83%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

To 4-ethyl-N-isobutylaniline (50 mg, 0.282 mmol) in pyridine (1 mL) was added 4-{[(3,5-dimethyl-4-isoxazolyl)methyl]oxy}benzenesulfonyl chloride (94 mg, 0.310 mmol) and the reaction stood at room temperature, in air, for 16 hours. The crude was then purified by MDAP (Method F), to provide 103.6 mg of desired product. LCMS (M+1) 443, RT 1.39 mins.

후처리

  1. customThe crude was then purified by MDAP (Method F)

출처 및 근거

ORD 기록
ord-4112b51de7e14304960be5b5953077f5
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09150508B2

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