Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
N,4-Dimethylcyclohexanamine → N-(4-hydroxy-2-methylphenyl)-6-[methyl(4-methylcyclohexyl)amino]pyrimidine-4-carboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | N,4-Dimethylcyclohexanamine | HCID 4962029 | — |
| 반응물 | 6-chloro-N-(4-hydroxy-2-methylphenyl)pyrimidine-4-carboxamide | HCID 59447105 | — |
| 생성물 | N-(4-hydroxy-2-methylphenyl)-6-[methyl(4-methylcyclohexyl)amino]pyrimidine-4-carboxamide | HCID 25182771 | — |
반응 단계
Following the general method as outlined in Example 20, starting from 6-chloro-N-(4-hydroxy-2-methylphenyl)pyrimidine-4-carboxamide (Intermediate 8) and N,4-dimethylcyclohexanamine (Enamine), the title compound was obtained as a mixture of cis-trans stereoisomers, as a yellow solid after purification by column chromatography (silica) eluting with cyclohexane containing increasing amounts of EtOAc.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09150519B2 |
| 출처 데이터셋 | uspto-grants-2015_10 |
| ORD ID | ord-5391c4b3de4842f0843773560565830f |
| 출처 메모 | uspto-grants-2015_10 |