6-methyl-1H-indazol-5-amine → 6-((cyclopropylmethyl)(propyl)amino)-N-(6-methyl-1H-indazol-5-yl)pyrimidine-4-carboxamide

HRID 1746748노트

반응식

HRID 1746748 반응식
[CH:1]1([CH2:4][N:5]([CH2:15][CH2:16][CH3:17])[C:6]2[N:11]=[CH:10][N:9]=[C:8]([C:12]([OH:14])=O)[CH:7]=2)[CH2:3][CH2:2]1.[CH3:18][C:19]1[CH:27]=[C:26]2[C:22]([CH:23]=[N:24][NH:25]2)=[CH:21][C:20]=1[NH2:28]>>[CH:1]1([CH2:4][N:5]([CH2:15][CH2:16][CH3:17])[C:6]2[N:11]=[CH:10][N:9]=[C:8]([C:12]([NH:28][C:20]3[CH:21]=[C:22]4[C:26](=[CH:27][C:19]=3[CH3:18])[NH:25][N:24]=[CH:23]4)=[O:14])[CH:7]=2)[CH2:2][CH2:3]1

참가 물질

3

반응물 2

HCID 14825826-methyl-1H-indazol-5-amineHCID 594470006-[(Cyclopropylmethyl)(propyl)amino]pyrimidine-4-carboxylic acid2회

생성물 1

HCID 251829156-((cyclopropylmethyl)(propyl)amino)-N-(6-methyl-1H-indazol-5-yl)pyrimidine-4-carboxamide

실험 절차

Following the general method as outlined in Example 1, starting from 6-[(cyclopropylmethyl)(propyl)amino]pyrimidine-4-carboxylic acid (Intermediate 21) and 6-methyl-1H-indazol-5-yl-amine (Bionet), the title compound was obtained as a pale brown solid.

출처 및 근거

ORD 기록
ord-90e2cc2648fc488aa059ab8e5f01af76
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09150519B2

반응 노트

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