(S)-2-(2-Nitro-phenylamino)-propionic acid tert-butyl ester → (S)-2-(2-Amino-phenylamino)-propionic acid tert-butyl ester

HRID 1747386노트

반응식

HRID 1747386 반응식
[C:1]([O:5][C:6](=[O:19])[C@@H:7]([NH:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[N+:16]([O-])=O)[CH3:8])([CH3:4])([CH3:3])[CH3:2]>CO.[Pd]>[C:1]([O:5][C:6](=[O:19])[C@@H:7]([NH:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[NH2:16])[CH3:8])([CH3:2])([CH3:3])[CH3:4]

참가 물질

4

반응물 1

HCID 59497415(S)-2-(2-Nitro-phenylamino)-propionic acid tert-butyl ester

생성물 1

HCID 59497437(S)-2-(2-Amino-phenylamino)-propionic acid tert-butyl ester수율 105.8%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

To a solution of (S)-2-(2-Nitro-phenylamino)-propionic acid tert-butyl ester (1.6 g, 6.0 mmol) in MeOH (20 mL) was added a slurry of 10% Pd/C (dry) (300 mg). The reaction mixture was degasses using house vacuum aspirator and then saturated with H2 gas in balloon. The reaction mixture was stirred at room temperature for 16 h. The reaction mixture was then filtered through a celite and the filtrate was concentrated to afford 1.5 g (100%) of the desired product as a dark brown oily residue. This product was used for the next reaction without purification.

후처리

  1. filtrationThe reaction mixture was then filtered through a celite
  2. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-d68b5dac7c4546a0829b4defaeedd18c
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09150556B2

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