[1-(2-Nitro-phenylamino)-cyclohexyl]-acetic acid methyl ester → [1-(2-Amino-phenylamino)-cyclohexyl]-acetic acid methyl ester

HRID 1747400노트

반응식

HRID 1747400 반응식
[CH3:1][O:2][C:3](=[O:21])[CH2:4][C:5]1([NH:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[N+:18]([O-])=O)[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6]1>CCO.[Pd]>[CH3:1][O:2][C:3](=[O:21])[CH2:4][C:5]1([NH:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[NH2:18])[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6]1

참가 물질

4

반응물 1

HCID 59497614[1-(2-Nitro-phenylamino)-cyclohexyl]-acetic acid methyl ester

생성물 1

HCID 59497703[1-(2-Amino-phenylamino)-cyclohexyl]-acetic acid methyl ester수율 99%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

A mixture of [1-(2-nitro-phenylamino)-cyclohexyl]-acetic acid methyl ester (230 mg, 0.79 mmol), 10% Pd/C (80 mg) in EtOH (20 mL) under H2 atmosphere at room temperature was stirred for 16 h. The reaction mixture was filtered and the organic layer was concentrated to give the desired [1-(2-amino-phenylamino)-cyclohexyl]-acetic acid methyl ester (205 mg, 99%).

후처리

  1. filtrationThe reaction mixture was filtered
  2. concentrationthe organic layer was concentrated

출처 및 근거

ORD 기록
ord-08d2d7a7e0fb4a5eb5b86790c3feb5a5
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09150556B2

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