Methyl 2-((2-nitrophenyl)amino)benzoate → Methyl 2-(2-aminoanilino)benzoate

HRID 1747427노트

반응식

HRID 1747427 반응식
[CH3:1][O:2][C:3](=[O:20])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[NH:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[N+:17]([O-])=O>CCOC(C)=O.[Pd]>[CH3:1][O:2][C:3](=[O:20])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[NH:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[NH2:17]

참가 물질

4

반응물 1

HCID 292094Methyl 2-((2-nitrophenyl)amino)benzoate

생성물 1

HCID 13114778Methyl 2-(2-aminoanilino)benzoate수율 93%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8857Ethyl Acetate용매

실험 절차

2-(2-Nitro-phenylamino)-benzoic acid methyl ester (200 mg, 0.74 mmol) is suspended in EtOAc (5.0 mL)) and 10% Pd/C wet (78 mg, 0.073 mmol) is added into it. A H2 balloon is attached to the reaction flask and the reaction mixture is stirred under H2 for 20 hrs. Then the Pd/C is filtered and the filtrated is concentrated to give 165 mg (93%) of 2-(2-Amino-phenylamino)-benzoic acid methyl ester.

후처리

  1. additionis added into it
  2. filtrationThen the Pd/C is filtered
  3. concentrationthe filtrated is concentrated

출처 및 근거

ORD 기록
ord-20e7940e4e344a9ba387c3c222c36f67
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09150556B2

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