Aluminium lithium hydride → HCID 59497624, 화합물

HRID 1747436노트

반응식

HRID 1747436 반응식
C[O:2][C:3]([C:5]1[C:13]2[N:9]([C:10]([CH3:15])=[C:11]([CH3:14])[CH:12]=2)[CH:8]=[CH:7][CH:6]=1)=O.[H-].[H-].[H-].[H-].[Li+].[Al+3]>CCOCC.C1COCC1>[CH3:14][C:11]1[CH:12]=[C:13]2[N:9]([C:10]=1[CH3:15])[CH:8]=[CH:7][CH:6]=[C:5]2[CH2:3][OH:2]

참가 물질

5

반응물 2

HCID 21226445Aluminium lithium hydrideHCID 59497655HCID 59497655, 화합물

생성물 1

HCID 59497624HCID 59497624, 화합물

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 8028Tetrahydrofuran용매

실험 절차

A solution of the 2,3-dimethyl-indolizine-8-carboxylic acid methyl ester (265 mg, 1.3 mmol) in ether (10 ml) was cooled to 0° C. and treated with LAH (1.0M in THF, 1.6 ml, 1.6 mmol, dropwise addition). After 3.5 h the reaction was quenched with sodium sulfate decahydrate (added in small portions until gas evolution ceased). The resulting mixture was stirred for 0.5 h and the precipitated solids were removed via filtration and washed with EtOAc. The combined filtrates were concentrated to give the product which was used without further purification.

후처리

  1. addition1.6 ml, 1.6 mmol, dropwise addition)
  2. customAfter 3.5 h the reaction was quenched with sodium sulfate decahydrate (added in small portions until gas evolution ceased)
  3. customthe precipitated solids were removed via filtration
  4. washwashed with EtOAc
  5. concentrationThe combined filtrates were concentrated
  6. customto give the product which
  7. customwas used without further purification

출처 및 근거

ORD 기록
ord-8191f7235c714ddbb17dc534d885c7d8
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09150556B2

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