Trifluoroacetic acid → HCID 67361638, 화합물

HRID 1747474노트

반응식

HRID 1747474 반응식
C(OC([N:8]1[C:16]2[C:11](=[C:12]([CH2:18][N:19]3[C:23]4[CH:24]=[CH:25][CH:26]=[CH:27][C:22]=4[N:21]([CH2:28][CH2:29][C:30]([O:32][CH3:33])=[O:31])[C:20]3=[O:34])[CH:13]=[C:14]([Cl:17])[CH:15]=2)[CH:10]=[CH:9]1)=O)(C)(C)C.FC(F)(F)C(O)=O>ClCCl.CO>[CH3:33][O:32][C:30](=[O:31])[CH2:29][CH2:28][N:21]1[C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=2[N:19]([CH2:18][C:12]2[CH:13]=[C:14]([Cl:17])[CH:15]=[C:16]3[C:11]=2[CH:10]=[CH:9][NH:8]3)[C:20]1=[O:34]

참가 물질

5

반응물 2

HCID 6422Trifluoroacetic acidHCID 59497231HCID 59497231, 화합물

생성물 1

HCID 67361638HCID 67361638, 화합물수율 100%

시약·촉매·용매 2

HCID 887Methanol용매HCID 6344Dichloromethane용매

실험 절차

6-Chloro-4-[3-(2-methoxycarbonyl-ethyl)-2-oxo-2,3-dihydro-benzoimidazol-1-ylmethyl]-indole-1-carboxylic acid tert-butyl ester (570 mg 1.1 mmol) is dissolved in 2.5 mL of dichloromethane and 2.5 mL of trifluoroacetic acid is added. The reaction is stirred for one hour, and then the solvent evaporated in vacuo to give an oil. The oil is taken up 3× in methanol and evaporated in vacuo to give the desired compound (450 mg, 1.1 mmol, 100%)

후처리

  1. customthe solvent evaporated in vacuo
  2. customto give an oil
  3. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-bce96be812e2441eae8e836ea596d406
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09150556B2

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