Methanol → 3-Methyl-indan-1-ylamine

HRID 1747573

반응식

HRID 1747573 반응식
C[CH:2]1[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[N:11]O.[CH3:13]O>[Pd]>[CH3:13][CH:10]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]([NH2:11])[CH2:2]1

참가 물질

4

반응물 2

HCID 887MethanolHCID 73454082Methylindan-1-one oxime

생성물 1

HCID 227426043-Methyl-indan-1-ylamine수율 96%

시약·촉매·용매 1

HCID 23938Palladium촉매

실험 절차

A mixture of-methylindan-1-one oxime (223 mg, 1.38 mmol) and 10% palladium on carbon (14.7 mg, 50% water wet) in MeOH (5.00 mL) was stirred under an atmosphere of hydrogen overnight. The mixture was then filtered through celite, washed through with MeOH and the combined filtrates were concentrated in vacuo to afford the title compound (195 mg, 96%). 1H NMR (CDCl3, 300 MHz) δ: 7.39-7.14 (m, 4H), 4.26 (dd, J=7.2, 9.4 Hz, 1H), 3.13-2.96 (m, 1H), 2.71 (ddd, J=6.9, 6.9, 12.5 Hz, 1H), 1.75 (bs, 2H), 1.35 (d, J=6.8 Hz, 3H), 1.25 (ddd, J=9.9, 9.9, 11.7 Hz, 1H) ppm.

후처리

  1. filtrationThe mixture was then filtered through celite
  2. washwashed through with MeOH
  3. concentrationthe combined filtrates were concentrated in vacuo

출처 및 근거

ORD 기록
ord-f5fd6522820e4428a39e97362d67bc3f
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09150525B2

연결된 노트

불러오는 중…