Benzene, 1-(1,1-dimethylethoxy)-2-nitro- → HCID 14763309, 화합물

HRID 1747769노트

반응식

HRID 1747769 반응식
[C:1]([O:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[N+:12]([O-])=O)([CH3:4])([CH3:3])[CH3:2]>CO.[Pd]>[C:1]([O:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[NH2:12])([CH3:4])([CH3:2])[CH3:3]

참가 물질

4

반응물 1

HCID 10997909Benzene, 1-(1,1-dimethylethoxy)-2-nitro-

생성물 1

HCID 14763309HCID 14763309, 화합물수율 97.7%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

To a solution of 1-tert-butoxy-2-nitrobenzene (Journal of Organic Chemistry, 1998, 63, 25, 9495-9496.) (15.0 g) in methanol (300 mL) was added 10% palladium on carbon (1.67 g), and the mixture was stirred at room temperature for 30 hr under a hydrogen atmosphere. Palladium on carbon was removed by filtration, and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane/ethyl acetate) to give the title compound (12.4 g).

후처리

  1. customPalladium on carbon was removed by filtration
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. customThe residue was purified by silica gel column chromatography (hexane/ethyl acetate)

출처 및 근거

ORD 기록
ord-51075b9c336f441a9ed19910bd98ade2
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09150588B2

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