Acetic Acid → 2-Acetyl-3-hydroxy-6-phenyl-4H-pyran-4-one

HRID 1747774노트

반응식

HRID 1747774 반응식
[C:1]1([C:7](=[O:17])[CH2:8][C:9](=[O:16])[C:10](=[O:15])[CH2:11][C:12](=[O:14])[CH3:13])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(O)(=O)C.C(O)(=O)C.IC1C=CC=CC=1.C(O)(=O)C>O>[C:12]([C:11]1[O:17][C:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)=[CH:8][C:9](=[O:16])[C:10]=1[OH:15])(=[O:14])[CH3:13]

참가 물질

5

반응물 3

HCID 176Acetic AcidHCID 12217721Iodo benzene diacetateHCID 132009181-Phenylheptane-1,3,4,6-tetrone

생성물 1

HCID 132009232-Acetyl-3-hydroxy-6-phenyl-4H-pyran-4-one수율 14%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 1-phenylheptane-1,3,4,6-tetrone (2.3 g), iodobenzene diacetate (6.7 g) and acetic acid (80 mL) was stirred at room temperature for 16 hr, the reaction mixture was diluted with water, and the mixture was extracted with ethyl acetate. The extract was dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (0.32 g).

후처리

  1. extractionthe mixture was extracted with ethyl acetate
  2. dry with materialThe extract was dried over anhydrous magnesium sulfate
  3. concentrationconcentrated under reduced pressure
  4. customThe residue was purified by silica gel column chromatography (ethyl acetate/hexane)

출처 및 근거

ORD 기록
ord-00344df25fe243fab4fc1cd6298b2e0f
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09150588B2

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