Sulfuric Acid → HCID 86663613, 화합물

HRID 1747862노트

반응식

HRID 1747862 반응식
[F:1][C:2]1([F:16])[O:7][C:6]2[CH:8]=[CH:9][C:10]([C:12]#[N:13])=[CH:11][C:5]=2[O:4][C:3]1([F:15])[F:14].S(=O)(=O)(O)[OH:18]>O>[F:16][C:2]1([F:1])[O:7][C:6]2[CH:8]=[CH:9][C:10]([C:12]([NH2:13])=[O:18])=[CH:11][C:5]=2[O:4][C:3]1([F:14])[F:15]

참가 물질

4

반응물 2

HCID 1118Sulfuric AcidHCID 27766192,2,3,3-Tetrafluoro-1,4-benzodioxane-6-carbonitrile

생성물 1

HCID 86663613HCID 86663613, 화합물

시약·촉매·용매 1

HCID 962Water용매2회

반응 조건

온도
40 °C

실험 절차

To 2,2,3,3-tetrafluoro-2,3-dihydrobenzo[b][1,4]dioxine-6-carbonitrile (200 mg) were added concentrated sulfuric acid (2 mL) and water (0.3 mL) at room temperature. The reaction mixture was stirred at 40° C. for 3 hr, water was added and the mixture was stirred for 40 min at room temperature. The resulting solid was collected by filtration, washed with purified water, and dried under reduced pressure to give the title compound (190.6 mg).

후처리

  1. stirringthe mixture was stirred for 40 min at room temperature
  2. filtrationThe resulting solid was collected by filtration
  3. washwashed with purified water
  4. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-9f90c4b3013f405d84c49f06e735a90c
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09150591B2

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