Aluminium lithium hydride → HCID 67983881, 화합물

반응식

[CH:1]1([C:4]2[O:8][N:7]=[C:6]([CH:9]3[CH2:14][CH2:13][C:12]([CH3:16])([CH3:15])[CH2:11][CH2:10]3)[C:5]=2[C:17](OC)=[O:18])[CH2:3][CH2:2]1.[H-].[H-].[H-].[H-].[Li+].[Al+3]>>[CH:1]1([C:4]2[O:8][N:7]=[C:6]([CH:9]3[CH2:14][CH2:13][C:12]([CH3:15])([CH3:16])[CH2:11][CH2:10]3)[C:5]=2[CH2:17][OH:18])[CH2:3][CH2:2]1

참가 물질

반응물 2

HCID 21226445Aluminium lithium hydride

HCID 67983290HCID 67983290, 화합물

생성물 1

HCID 67983881HCID 67983881, 화합물

실험 절차

(5-cyclopropyl-3-(4,4-dimethylcyclohexyl)isoxazol-4-yl)methanol (I-9F) was prepared by reaction of methyl 5-cyclopropyl-3-(4,4-dimethylcyclohexyl)isoxazole-4-carboxylate and LiAlH4 following the same protocol as described for I-6F. 1H NMR (400 MHz, CDCl3) δ 4.56 (s, 3H), 2.65 (m, 1H), 2.05-1.99 (m, 1H), 1.81-1.75 (m, 4H), 1.52-1.48 (m, 2H), 1.33-1.28 (m, 2H), 1.14-1.10 (m, 2H), 1.04-1.01 (m, 2H), 0.95 (s, 3H), 0.94 (s, 3H). MS m/z 250.1 (M+1).

출처 및 근거

ORD 기록: ord-b9eec4352b6c480b97840dc9030951cf
출처 데이터셋: uspto-grants-2015_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09150568B2

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