3-Cyclopropyl-3-Oxopropionic Acid Methyl Ester → HCID 67983906, 화합물

반응식

[OH:1][N:2]=[C:3](Cl)[CH:4]1[CH2:10][CH2:9][CH:8]2[CH:6]([CH2:7]2)[CH2:5]1.[CH:12]1([C:15](=O)[CH2:16][C:17]([O:19]C)=[O:18])[CH2:14][CH2:13]1>>[CH:6]12[CH2:7][CH:8]1[CH2:9][CH2:10][CH:4]([C:3]1[C:16]([C:17]([OH:19])=[O:18])=[C:15]([CH:12]3[CH2:14][CH2:13]3)[O:1][N:2]=1)[CH2:5]2

참가 물질

반응물 2

HCID 101300163-Cyclopropyl-3-Oxopropionic Acid Methyl Ester

HCID 86704407HCID 86704407, 화합물

생성물 1

HCID 67983906HCID 67983906, 화합물

실험 절차

3-(Bicyclo[4.1.0]heptan-3-yl)-5-cyclopropylisoxazole-4-carboxylic acid (I-12F) was prepared from N-hydroxybicyclo[4.1.0]heptane-3-carbimidoyl chloride and methyl 3-cyclopropyl-3-oxopropanoate following the same protocol as described for I-6E. MS m/z 248.1 (M+1).

출처 및 근거

ORD 기록: ord-431cce56764541a197f7e599b6af41ca
출처 데이터셋: uspto-grants-2015_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09150568B2

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